Fusion
Most Santa Fe night spots have more of a coffeehouse vibe than a dance-till-you-drop atmosphere, but dancing is available here, with occasional tango lessons. "Touristy" rather than "popular with the locals," as one might expect from its location near the Plaza; LGBT-oriented according to some, but not all, visitors.
Inn on the Alameda
Included in its rates is an afternoon wine and cheese reception, and with its location at the base of Canyon Road, it offers an easy way to relax after a day of gallery-hopping.
Second Street Brewery
Brewpub, with live music most evenings Thursday-Sunday and art exhibits this is Santa Fe, after all at other times. Note that they've been fined in the past by the state of New Mexico for permitting consumption of alcohol off grounds, so they may be sticklers for keeping your drink on-site. Second location: Second Street Brewpub at the Railyard. 1607 Paseo de Peralta #10.
Two of the ubiquitous alcoholic beverages in Santa Fe are the familiar margarita and the possibly-less-familiar sangria, a wine-based concoction incorporating fruit, more commonly associated with Spain and Central America. Most of the better New Mexican restaurants in town have their own house sangria; it goes well with New Mexican cuisine, and is claimed by some to be a useful antidote if the spicy food gets the better of you. It's considered much more of a day-to-day beverage here than in many other places. Visitors should note that the high altitude may increase sensitivity to alcohol.
Much of the beer consumed in the community is imported from Mexico, and there are also a few microbreweries. If you're sticking with non-alcoholic beverages, a tip: Many locals advise against having soft drinks with New Mexican food, instead preferring iced tea. This preference is based on the belief that carbonation in drinks including beer tends to accentuate the spiciness of the chile peppers and cause the spicy component to hang around in the throat, while iced tea mutes it. Do the experiment, or at least have your designated driver do it.
Secreto Lounge
One of the best places for people-watching in all of Santa Fe. The crowd tends to be more sedate here than at some other places. Two great guys to look for here. Daniel and Chris, both award winning mixologists.
Cities of Gold
Changes in New Mexico laws during the 1990s led to the development of casinos at a number of nearby American Indian pueblos. The closest to Santa Fe are along US 285 on the way to Pojoaque. Big-name acts occasionally appear and liven up the night life, although you're as likely to catch a falling star on his/her way down-and-out as a current, lively act. The two listed here may run shuttle services connecting to the major in-town hotels; inquire locally as to availability.
Several of the local-style bars can be found on Cerrillos Road and St. Michaels Drive, if you'd prefer to avoid the touristy places. Warning: some of these can get rowdy, and DUI is a problem in the area as well.